机体脂质代谢失衡是引起非酒精性脂肪肝病(non-alcoholic fatty liver disease，NAFLD)、高脂血症等一系列代谢性疾病的重要因素。肝X受体是核受体超家族的一员，通过调控胆固醇的吸收、转运、逆转运、生物合成等功能维持机体胆固醇稳态；通过调节脂肪酸从头合成来维持体内脂肪酸的平衡，在维持机体脂质动态平衡中发挥着重要的作用。“,”The imbalance of lipid metabolism is an important factor causing a series of metabolic diseases such as non-alcoholic fatty liver disease (NAFLD) and hyperlipidemia.Liver X receptors is a member of the nuclear receptor superfamily, which maintains cholesterol homeostasis by regulating cholesterol absorption, transport, reverse cholesterol transport, biosynthesis and other functions.It plays an important role in maintaining lipid homeostasis by regulating de novo fat synthesis to maintain the balance of fatty acids in the body.