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通过用啮齿类动物移植性肿瘤对1-(8-氯丙基)-2氯哌甲啶氢溴酸盐(CAP-2)的抗肿瘤作用和作用方式的研究,表明该药有可能作为一种化疗药应用。另外,某些抗精神病药能提高环磷酰胺对小鼠S 180的疗效。苯骈二氮杂草衍生物与BCNU和咖啡因联合对小鼠L_(1210)也显示增强作用,本文观察了21种中枢神经系统抑制药与CAP-2以及其他抗癌药联合对大鼠腹水型肝癌AH_(13)和AH_(44)细胞株的影响。 CAP-2由作者所在实验室合成。所用的其他抗癌药有丝裂霉素、环磷酰胺和5-氟尿嘧啶,中枢神经系统抑制药包括盐酸氯胺酮、硝基安定、去甲羟安定、
The antitumor effect and mode of action of 1- (8-chloropropyl) -2-piperiparadine hydrobromide (CAP-2) in rodent transplanted tumors suggest that the drug may be used as a Application of chemotherapy drugs. In addition, some antipsychotic drugs can improve the efficacy of cyclophosphamide on mice S180. Benzodiazepine derivatives combined with BCNU and caffeine also showed potentiation on L 1210 in mice. In this paper, 21 CNS inhibitors combined with CAP-2 and other anticancer drugs were tested against rat ascites Type hepatocellular carcinoma AH_ (13) and AH_ (44) cell lines. CAP-2 synthesized by the author’s laboratory. Other anticancer drugs used are mitomycin, cyclophosphamide and 5-fluorouracil, and central nervous system depressants include ketamine hydrochloride, nitrazepam, norcoxetine,