目的探讨胃食管反流病(GERD)的流行病学特点及与牙周疾病之间的关系。方法对于2014年4月至2016年4月就诊于新疆维吾尔自治区人民医院口腔科的80例GERD患者和71名正常人进行GERD相关检查和牙周疾病检查,牙周检查以社区牙周指数(CPI)和附着丧失(AL)作为诊断标准。结果 GERD患者与对照组比较,年龄、性别等指标之间无统计学差异(P>0.05),而民族、BMI、吸烟比例等指标之间有统计学差异(P<0.05),GERD患者中维吾尔族较汉族多(χ~2=4.447,P=0.035),BMI高于对照组(t=2.463,P=0.015),GERD组吸烟比例较对照组高(χ~2=5.234,P=0.022),GERD患者牙周炎患病率较对照组高(χ~2=4.113,P=0.043),在GERD患者中牙周炎严重程度较对照组高。通过Logistics回归分析可知年龄是牙周炎的危险因素(OR=1.091,95%CI 1.052~1.132),非GERD(OR=0.332,95%CI 0.176~0.624)和不吸烟(OR=0.422,95%CI 0.210~0.847)是牙周疾病的保护因素。结论与吸烟、年龄等危险因素一样,GERD是牙周疾病的危险因素之一。 Objective To investigate the epidemiological characteristics of gastroesophageal reflux disease (GERD) and its relationship with periodontal disease. Methods 80 patients with GERD and 71 normal persons attending the Department of Stomatology, People’s Hospital of Xinjiang Uyghur Autonomous Region from April 2014 to April 2016 were examined by GERD and periodontal disease. The periodontal examination was performed on the basis of community-based periodontal index (CPI ) And loss of attachment (AL) as diagnostic criteria. Results There was no significant difference in age, gender and other indicators between GERD patients and controls (P> 0.05), but there was a significant difference among nationalities, BMI and smoking percentage (P <0.05). Among GERD patients, Uyghur (Χ ~ 2 = 4.447, P = 0.035). The BMI was higher in the GERD group than in the control group (χ ~ 2 = 5.234, P = 0.022) The prevalence of periodontitis in GERD patients was higher than that of the control group (χ ~ 2 = 4.113, P = 0.043). The severity of periodontitis in GERD patients was higher than that in the control group. Logistic regression analysis showed that age was the risk factor of periodontitis (OR = 1.091,95% CI 1.052-1.13 2), non-GERD (OR = 0.332,95% CI 0.176-0.624) CI 0.210 ~ 0.847) is a protective factor of periodontal disease. Conclusions GERD is one of the risk factors of periodontal disease, just as risk factors such as smoking and age are.