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目的:对我院1998年1月至2001年6月自发呈报的163例药物不良反应(ADR)报告进行分析。方法:采用描述性研究方法对ADR报告进行分类。结果:涉及药物124种,单一用药85例,合并用药78例;ADR程度分级,重度22例,中度82例,轻度59例;因果关系评定为肯定9例,很可能114例,可能36例,可疑4例;对症治疗133例,未进行特殊处理30例;痊愈130例,好转31例,死亡2例;使原患病程延长12例,病情加重3例。抗生素引起的ADR居首位,为 53.89％;ADR中引起皮肤及附件损害最多,为71.34％。结论:应加强ADR知识的宣传,将药品不良反应监测放在与治疗作用同等重要的位置上,尽可能避免或减少ADR的重复发生,达到用药有效安全的目的。
OBJECTIVE: To analyze 163 cases of ADR reported spontaneously from January 1998 to June 2001 in our hospital. Methods: Descriptive methods were used to classify ADR reports. Results: There were 124 drugs, 85 single drugs and 78 drugs in combination. ADR was graded in 22 cases, moderate in 82 cases and mild in 59 cases. There were 9 cases in causation, 114 in probable cases, and possibly 36 Cases, suspicious 4 cases; symptomatic treatment of 133 cases, without special treatment in 30 cases; cured 130 cases, improved in 31 cases, 2 died; so that the original course of disease extended in 12 cases, the disease aggravated in 3 cases. ADR caused by antibiotics was the highest, accounting for 53.89%. ADR caused the most damage to skin and appendages, accounting for 71.34%. Conclusion: The publicity of ADR knowledge should be strengthened, and adverse drug reaction monitoring should be placed on the same important position as the therapeutic effect, avoiding or reducing the recurrence of ADR as much as possible, so as to achieve effective and safe medication.