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肿瘤干细胞理论的提出使靶向性杀伤肿瘤干细胞成为可能,而肿瘤干细胞的研究关键是寻找特异性表面分子标志物。表面黏附分子CD133是一种跨膜糖蛋白,其表达的一个显著特点就是,随着细胞的分化迅速下调,这使得它成为一个分离和鉴定干细胞和祖细胞的独特分子标志。作为理想的分子标志,CD133在脑肿瘤、前列腺癌、结肠癌、喉癌和肝癌等多种实体肿瘤干细胞分离研究中发挥着重要作用。多种实验证实,CD133+细胞与肿瘤信号转导、肿瘤免疫逃逸、药物耐受和放疗抵抗均有相关性,CD133+细胞可望成为肿瘤治疗的新靶点。
The theory of cancer stem cells makes it possible to kill cancer stem cells specifically, and the key to the research of tumor stem cells is to search for specific surface molecular markers. The surface adhesion molecule CD133, a transmembrane glycoprotein, is notable for its expression, which is a unique molecular marker for the isolation and characterization of stem and progenitor cells as cells rapidly differentiate. As an ideal molecular marker, CD133 plays an important role in the study of stem cell isolation of various solid tumors such as brain tumor, prostate cancer, colon cancer, laryngeal cancer and liver cancer. A variety of experiments confirmed that CD133 + cells and tumor signal transduction, tumor immune escape, drug resistance and radiation resistance are related, CD133 + cells is expected to become a new target for cancer treatment.