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目的:研究葛根素注射液对小鼠肠缺血再灌注所致肝损伤的保护作用。方法:按区组随机分组方法将小鼠分为模型组、假手术组及葛根素注射液(100,150,200 mg/kg)组,通过夹闭肠系膜上动脉建立肠缺血再灌注肝损伤模型。再灌注60 min后,取肝组织,测定肝组织中超氧化物歧化酶(SOD)活力和丙二醛(MDA)水平,光镜下观察肝组织形态学改变。结果:葛根素注射液可增强SOD活力,降低MDA水平,减轻肝组织形态学损伤。结论:葛根素注射液对小鼠肠缺血再灌注肝损伤具有一定的保护作用。
Objective: To study the protective effect of puerarin on liver injury induced by intestinal ischemia-reperfusion in mice. METHODS: The mice were divided into model group, sham operation group and puerarin injection group (100, 150, 200 mg/kg) group by random grouping method. The intestinal ischemia-reperfusion liver injury model was established by clamping the superior mesenteric artery. After 60 min of reperfusion, the liver tissue was taken to determine the activity of superoxide dismutase (SOD) and malondialdehyde (MDA) in liver tissue. Morphological changes of liver tissue were observed under light microscope. RESULTS: Puerarin injection enhanced the activity of SOD, reduced the level of MDA and reduced the morphological damage of liver tissue. Conclusion: Puerarin injection has a certain protective effect on liver injury induced by intestinal ischemia-reperfusion in mice.