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Objective:To investigate die ameliorative effect of dietary inclusion of garlic(Allium sativum)on gentamycin-induced hepatotoxicity in rats.Methods:Adult male rats were randomly divided into four groups with sis animals in each group.Groups 1 and 2 were fed basal diet while Groups 3 and 4 were fed diets containing 2%and 4%garlic respeetively for 27 d prior to gentamycin administration.Hepatotoxicity was induced by the intraperitoneal administration at gentamycin(100 mg/kg body weight)for 3 d.The liver and plasma were studied for hepatotoxicity and antioxidant indices.Results:Gentamycin induces hepatic damage as revealed by significant(P<0.05)elevation of liver damage marker enzymes(aspartate transaminase and alanine aminotransferase)and reduction in plasma albumin level.Gentamycin also eaused a significant(P<0.05)alteration in plasma and liver enzymatic(catalase,glutathione and super oxygen dehydrogenises)and non-enzymatic(glutathione and vitamin C)antioxidant indices with concomitant increase in the malondialdehyde content;however,there was a significant(P<0.05)restoration of the antioxidant status coupled with significant(P<0.05)decrease in the tissues malondialdehyde content,following consumption of diets containing garlic.Conclusions:These results suggest that dietary inclusion of garlic powder could protect against gentamycin-induced hepatotoxicity,improve antioxidant status and modulate oxidative stress;a function attributed to their phenolic constituents.
Objective: To investigate die ameliorative effect of dietary inclusion of garlic (Allium sativum) on gentamycin-induced hepatotoxicity in rats. Methods: Adult male rats were randomly divided into four groups with sis animals in each group. Group 1 and 2 were fed basal diet while Groups 3 and 4 were fed diets containing 2% and 4% garlic respeetively for 27 d prior to gentamycin administration. Hepatotoxicity was induced by the intraperitoneal administration at gentamycin (100 mg / kg body weight) for 3 days. The liver and plasma were studied for hepatotoxicity and antioxidant indices. Results: Gentamycin induces hepatic damage as revealed by significant (P <0.05) elevation of liver damage marker enzymes (aspartate transaminase and alanine aminotransferase) and reduction in plasma albumin level. Gentamycin also eaused a significant (P < 0.05) alteration in plasma and liver enzymatic (catalase, glutathione and super oxygen dehydrogenises) and non-enzymatic (glutathione and vitamin C) antioxidant indices with concomitant increase in the malondialdehyde content; however, there was a significant (P <0.05) restoration of the antioxidant status coupled with significant (P <0.05) decrease in the tissues malondialdehyde content, the following consumption of diets containing garlic. dietary inclusion of garlic powder could protect against gentamycin-induced hepatotoxicity, improve function status and modulate oxidative stress; a function attributed to their phenolic constituents.