糖尿病心血管疾病的发生率和死亡率明显高于非糖尿病人群，动物实验和人体研究均表明冠状动脉病变是糖尿病致死的首要原因，特别是病程较长时，冠状动脉粥样硬化发生率更高。另一方面，心绞痛或心肌缺血也常发生在无明显心外膜冠脉狭窄病人中，近期许多动物实验和临床研究已证 Diabetes cardiovascular disease incidence and mortality were significantly higher than non-diabetic population, animal studies and human studies have shown that coronary artery disease is the leading cause of death caused by diabetes, especially when longer duration, coronary atherosclerosis higher incidence . On the other hand, angina pectoris or myocardial ischemia often occurs in patients with no obvious epicardial coronary artery stenosis. Recently, many animal experiments and clinical studies have proved