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为探讨骨髓移植(BMT)过程对红细胞生成素(Epo)生成和红系再生的影响,作者连续测定了17例造血系统恶性肿瘤BMT后血清Epo的变化;17例患者年龄在16～48岁,男性16例.女性2例。11例接受异基因骨髓移植(Allo-BMT),6例用自体外周血干细胞或自体骨髓输注救治(AR).预处理方案以环磷酰胺和马利兰或环磷酰胺和全身照射为主,Allo-BMT用环孢菌素,氨甲喋呤及强的松龙预防移植物抗宿主病(GVHD)。测定血清Epo采用放射免
To investigate the effect of bone marrow transplantation (BMT) process on erythropoietin (Epo) production and erythroid regeneration, the authors measured the changes of serum Epo in 17 hematopoietic malignancies after BMT. The 17 patients aged 16-48 years old, 16 males and 2 females. Eleven patients received allogeneic bone marrow transplantation (Allo-BMT) and 6 patients received autologous peripheral blood stem cell transplantation or autologous bone marrow infusion (AR) .The pretreatment regimen consisted of cyclophosphamide and melitrin or cyclophosphamide and systemic irradiation, and Allo -BMT Cyclosporine, methotrexate and prednisolone prevent graft versus host disease (GVHD). Determination of serum Epo using radioactive