已对胶原基因做了许多研究,在整个脊椎和无脊椎动物中,至少已发现15种这类基因而成为一个较大的家族。这些研究不仅能提示分子生物学的进化情况,且由它们在发育中被调节而决定着大部份组织结构的完整性并涉及到许多人类基因病。现已可得到I型胶原α_2链基因非常详细的说明。这一基因最明显的特征是除其大小和它在4万DN- Much research has been done on collagen genes, and at least 15 of these genes have been found throughout the vertebrates and invertebrates to become a larger family. These studies not only prompt the evolution of molecular biology, but are also regulated by their development to determine the structural integrity of most tissues and involve many human genetic diseases. Already available type I collagen α_2 chain gene is very detailed instructions. The most obvious feature of this gene is its size and its 40,000 DN-