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目的 :探讨母亲对氧磷酶 2基因 [二乙基对硝基苯磷酸酯酶 2基因 (PON2 148) ]多态性位点和细胞色素P45 0IIE1基因 (CYP2E1)多态性位点对低出生体重的影响。方法 :采用病例对照研究方法 ,使用统一设计的调查问卷 ,由经过培训的调查员于 1998至 1999年在安徽省安庆市各县级医院对入院分娩孕妇及其单胎、活产的低出生体重儿和正常出生体重的对照新生儿进行调查 ,共得到有效样本 2 31个母亲新生儿对 ,其中低出生体重组 6 5对 ,正常出生体重对照组 16 6对。结果 :单因素分析结果显示 ,突变纯合子基因型 /杂合子基因型与野生纯合子基因型比较 ,未见CYP2E1多态性位点和PON2 148多态性位点导致低出生体重的危险性有显著性增加。多因素Logistic回归模型经母亲年龄、文化程度、生育史 ,新生儿性别、孕周混杂因素调整后 ,可见CYP2E1多态性位点和PON2 148多态性位点均导致低出生体重的危险性增加 (CYP2E1,OR =2 .4,95 %CI为 1.17～ 4.89;PON2 148,OR =2 .16 ,95 %CI为 1.0 6～ 4.41) ,并且有显著的统计学意义。经进一步分析CYP2E1多态性位点和PON2 148多态性位点之间对低出生体重的影响 ,其结果显示 :这两个多态性位点之间无明显交互作用 ,它们是低出生体重的独立危险因素。结论 :CYP2E1多态性位点和PON2 148多态性?
OBJECTIVE: To investigate the relationship between the polymorphisms of the paired paraoxonase 2 gene (PON2 148) and the cytochrome P45 0IIE1 gene (CYP2E1) The impact of weight. Methods: A case-control study was conducted using a questionnaire of uniform design. The trained investigators from 1998 to 1999 in all county-level hospitals in Anqing City of Anhui Province reported low birth weight Children and normal birth weight control neonates were investigated, a total of 2 31 valid pairs of mothers were obtained, of which 65 pairs were low birth weight group and 16 6 normal birth weight control group. Results: The results of univariate analysis showed that there was no risk of low birth weight due to CYP2E1 polymorphism and PON2148 polymorphism in mutant homozygous genotypes / heterozygous genotypes compared with wild homozygous genotypes Significant increase. Multivariate logistic regression model adjusted for maternal age, education level, birth history, neonatal sex and gestational age confounding showed that CYP2E1 polymorphism site and PON2 148 polymorphism site both increased the risk of low birth weight (CYP2E1, OR = 2.4, 95% CI 1.17-4.99; PON2 148, OR = 2.16, 95% CI 1.06-4.41), with significant statistical significance. Further analysis of the effect of CYP2E1 polymorphisms and PON2 148 polymorphisms on low birth weight revealed no significant interaction between the two polymorphic loci and they were low birth weight Of independent risk factors. Conclusion: CYP2E1 polymorphism and PON2 148 polymorphism?