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目的探讨肠球菌属医院感染的危险因素,以制定有效的防护措施。方法对59例肠球菌属医院感染患者与59例对照病例进行了配比研究。结果单因素分析显示患者入院时的病情、是否合并泌尿系感染、白蛋白水平、侵入性操作和抗菌药物的使用在感染组与对照组病例中差异有统计学意义(P<0.05);多因素Logistic显示:患者入院时病情危重(OR=8.626)、有侵入性操作(OR=9.522)和应用头孢三代抗菌药物(OR=12.283)进行了回归方程(P<0,05);屎肠球菌感染病例中入院时病情危重、头孢三代抗菌药物应用者的比例较粪肠球菌感染病例中的比例高(50.00%vs6.67%,79.50%vs46.70%,P<0.05);粪肠球菌感染发生时间平均为入院后7.7 d,屎肠球菌感染时间平均为入院后15.0 d(P<0.05)。结论患者入院时病情危重、有侵入性操作和头孢三代抗菌药物的应用是肠球菌属医院感染的独立危险因素,而加强侵入性操作的过程管理、规范头孢三代抗菌药物的使用可以作为今后进行临床干预的可行策略。
Objective To explore the risk factors of enterococcal nosocomial infection in order to develop effective protective measures. Methods 59 cases of enterococci nosocomial infection and 59 cases of control were compared. Results Univariate analysis showed that there was significant difference between the infected group and the control group (P <0.05). The incidence of patients admitted to the hospital with or without urinary tract infection, albumin level, invasive procedures and use of antibacterials were significantly different (P <0.05) Logistic showed that the patients were admitted to hospital with critically ill patients (OR = 8.626), invasive procedures (OR = 9.522), and ceftriaxone antibiotics (OR = 12.283) The patients were admitted to hospital in critically ill condition, and the proportion of three cephalosporin antibacterial drug users was higher than that of Enterococcus faecalis infection (50.00% vs6.67%, 79.50% vs46.70%, P <0.05); Enterococcus faecalis infection occurred The average time was 7.7 days after admission, and the average time of Enterococcus faecium infection was 15.0 days after admission (P <0.05). Conclusions Patients admitted to hospital were in critical condition with invasive procedures and the use of three cephapresistant antibiotics was an independent risk factor for nosocomial infections of enterococci. Strengthening the process management of invasive procedures and standardizing the use of three generations of antibacterials could be used as clinical Possible strategy for intervention.