目的:探索化疗毒副作用与乙肝相关性和严重肝损害的可能性。方法:回顾性分析3例恶性肿瘤化疗后出现急性严重肝功能损害。结果:合并乙型病毒性肝炎患者是化疗出现肝损害的直接相关因素,特别是多周期化疗,严重者可致死,临床上尚无特效治疗手段。结论:化疗过程应避免致死性并发症的发生。 Objective: To explore the possibility of toxicities and side effects of chemotherapy associated with hepatitis B and severe liver damage. Methods: A retrospective analysis of 3 cases of malignant tumor after chemotherapy with acute severe liver damage. Results: Patients with hepatitis B were directly related to liver damage caused by chemotherapy, especially multi-cycle chemotherapy. In severe cases, they could be lethal and there was no effective treatment in clinic. Conclusion: The chemotherapy should avoid the fatal complications.