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目的 探讨硬皮病患者血液中血小板源生长因子（PDGF）水平和意义。方法 采用双抗体夹心ABC-ELISA法对硬皮病患者标本和正常人标本进行血小板生长因子的检测。结果 硬皮病患者组血清中 PDGF-AB含量为1586.4±683.7pg/ml;正常对照组血清中PDGF-AB含量为476.8±160.8pg/ml。硬皮病患者组血清中PDGF-AB含量明显高于正常对照组血清中PDGF-AB含量（P<0.01）。结论PDGF水乎的检测对硬皮病患者的辅助诊断、疗效观察以及预后判断有重要意义。
Objective To investigate the significance of blood platelet derived growth factor (PDGF) in patients with scleroderma. Methods The double antibody sandwich ABC-ELISA was used to detect platelet growth factor in patients with scleroderma and in normal subjects. Results The serum level of PDGF-AB in patients with scleroderma was 1586.4 ± 683.7 pg / ml, while the level of PDGF-AB in normal controls was 476.8 ± 160.8 pg / ml. The level of PDGF-AB in the serum of patients with scleroderma was significantly higher than that of the normal control (P <0.01). Conclusion The detection of PDGF is of great significance in the diagnosis of patients with scleroderma, the observation of the curative effect and the prognosis.