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目的探讨腹式及阴式子宫切除手术对患者机体应激反应的影响。方法选择47例子宫肌瘤手术患者,分为2组:经腹部切口手术组24例(腹式组),经阴道手术组23例(阴式组)。分别于术前、术后1h、术后1,3,5d采取病人外周静脉血,测定血清白细胞介素-6(IL-6)、皮质醇(Cor)水平,并进行比较。结果术前两组间所有指标无明显差异。两组术后1h、术后1dIL-6水平明显高于术前;阴式组Cor术后1h、术后1d明显高于术前水平,腹式组Cor术后1h、术后1,3d明显高于术前水平。术后1h腹式组IL-6,Cor水平明显高于阴式组。结论阴式或腹式子宫切除术都会引起一定的机体应激反应,阴式手术比腹式开放手术在术后早期更能减轻病人的应激反应。
Objective To investigate the effect of abdominal and vaginal hysterectomy on stress response in patients. Methods Forty-seven patients with uterine fibroid were selected and divided into two groups: 24 cases (abdominal group) and 23 cases (vaginal group) underwent transvaginal operation. Peripheral venous blood was collected before operation, 1h after operation, and 1,3 and 5 days after operation respectively. Serum levels of IL-6 and COR were measured and compared. Results There was no significant difference between the two groups before operation. The levels of IL-6 in the two groups at 1 h after operation and at 1 d after operation were significantly higher than those before operation. In Cor group, the Cor group at 1 h and 1 d postoperatively were significantly higher than those at preoperative and 1 h postoperatively Higher than the preoperative level. The levels of IL-6 and Cor in abdominal group 1 h after operation were significantly higher than those in the vaginal group. Conclusion Both vaginal and abdominal hysterectomy can cause certain body stress response. Vaginal surgery can relieve the patient’s stress response earlier than the open surgery.