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目的:研究血清肿瘤坏死因子α(TNF α)水平与2型糖尿病患者胰岛素抵抗、血糖及血脂的关系。方法:77例2型糖尿病患者按体重指数(BMI)分为两组,正常体重组(BMI<25 kg/m~2)53例,肥胖组(BMI≥25kg/m~2)24例。正常对照组30例。分别测定血清肿瘤坏死因子α(TNFα)、血糖、胰岛素和C肽,以及血脂(总胆固醇和甘油三酯)。结果:(1)2型糖尿病患者血清TNF α水平高于正常对照组(P<0.01)。(2)TNF α与胰岛素敏感性指数(ISI)呈负相关(P<0.05),与年龄呈正相关(r=0.364,P<0.01)。(3)2型糖尿病患者血清甘油三酯水平高于对照组(P<0.05)。结论:2型糖尿病患者血清TNF α水平升高,并与正常对照组间存在显著性差异[血清TNF α水平上升与胰岛素敏感性指数(ISI)降低及糖尿病的发生可能存在一定的关系]。2型糖尿病患者血脂异常主要表现为高甘油三酯血症。
Objective: To study the relationship between serum tumor necrosis factor α (TNF α) and insulin resistance, blood glucose and blood lipids in type 2 diabetic patients. Methods: Totally 77 patients with type 2 diabetes were divided into two groups according to body mass index (BMI): 53 in normal weight group (BMI <25 kg / m ~ 2) and 24 in obesity group (BMI≥25 kg / m ~ 2) Normal control group of 30 cases. Serum tumor necrosis factor alpha (TNFα), blood glucose, insulin and C-peptide, and blood lipids (total cholesterol and triglyceride) were measured. Results: (1) The level of serum TNFα in patients with type 2 diabetes mellitus was higher than that in normal controls (P <0.01). (2) TNFα was negatively correlated with insulin sensitivity index (ISI) (P <0.05), and positively correlated with age (r = 0.364, P <0.01). (3) The level of serum triglyceride in type 2 diabetes patients was higher than that in control group (P <0.05). CONCLUSIONS: Serum levels of TNFα are elevated in patients with type 2 diabetes mellitus, and there is a significant difference between the two groups. [There may be some relationship between the increase of serum TNFα level and the decrease of insulin sensitivity index (ISI) and diabetes mellitus.] Patients with type 2 diabetes dyslipidemia mainly hypertriglyceridemia.