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目的：探讨小儿生长痛的病理基础。方法：对照观察４８例生长痛患儿及３５例正常儿童足甲襞微循坏的形态、流态及血管袢周围状态等多项指标，并以加权积分法计算其积分值。结果：与对照组相比，发病组存在明显的微循环改变（Ｐ＜０．０１），主要表现为毛细血管管径缩小，管袢数目减少，管袢形态异常，以及管袢周围渗出、出血等。随着病情加重，微循环病理改变也加重，其甲襞微循环积分值也相应增大（Ｐ＜０．０１）。结论：微循环障碍是生长痛重要病理改变之一。
Objective: To investigate the pathological basis of pediatric growth pain. Methods: A total of 48 children with growth-induced pain and 35 normal children were enrolled in this study. The microcirculation morphology, flow pattern and peri-vascular environment were observed. The integrals were calculated by weighted integral method. Results: Compared with the control group, there was a significant change of microcirculation in the onset group (P <0.01), which was mainly manifested as a decrease in the capillary diameter, a decrease in the number of tubules, an abnormal morphology of the tubules, and oozing around the tubules, Bleeding and so on. As the disease progressed, the pathological changes of microcirculation also aggravated, and the integral value of microcirculation of formazan also increased accordingly (P <0.01). Conclusion: Microcirculation is one of the important pathological changes of growth pain.