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目的评价盐酸二甲双胍片联合阿卡波糖胶囊治疗2型糖尿病的疗效。方法 150例2型糖尿病患者,随机分为观察组和对照组,各75例。对照组采用盐酸二甲双胍片治疗,观察组采用盐酸二甲双胍片联合阿卡波糖胶囊治疗。比较两组患者的空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(GHb A1c)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、体质量指数(BMI)水平。结果治疗后,观察组患者的FBG为(5.32±2.15)mmol/L、2 h PG为(7.79±1.52)mmol/L、GHb A1c为(6.63±1.37)%,均低于对照组的(6.42±2.43)mmol/L、(8.65±1.87)mmol/L、(7.51±1.85)%,差异均有统计学意义(P<0.01)。治疗后,观察组患者的TG为(1.54±0.65)mmol/L、LDL-C为(2.72±0.97)mmol/L,均低于对照组的(1.93±0.84)mmol/L、(3.34±1.12)mmol/L,差异均有统计学意义(P<0.01)。观察组的BMI水平(24.15±5.75)kg/m~2和对照组(25.43±6.19)kg/m~2比较,差异无统计学意义(P>0.05)。结论盐酸二甲双胍片联合阿卡波糖胶囊治疗2型糖尿病的疗效显著,可以达到降低、稳定患者血糖的效果。
Objective To evaluate the efficacy of metformin hydrochloride tablets combined with acarbose capsules in the treatment of type 2 diabetes. Methods 150 patients with type 2 diabetes were randomly divided into observation group and control group, with 75 cases each. The control group was treated with metformin hydrochloride tablets. The observation group was treated with metformin hydrochloride tablets and acarbose capsules. Fasting blood glucose (FBG), 2 h PG, GHb A1c, TG, LDL-C, body mass index (BMI) level. Results After treatment, FBG in the observation group was (5.32 ± 2.15) mmol / L, PG (7.79 ± 1.52) mmol / L in 2 h and (6.63 ± 1.37)% in GHb A1c group were significantly lower than those in the control group ± 2.43) mmol / L, (8.65 ± 1.87) mmol / L and (7.51 ± 1.85)%, respectively, with statistical significance (P <0.01). After treatment, TG in the observation group was (1.54 ± 0.65) mmol / L and LDL-C was (2.72 ± 0.97) mmol / L, which were significantly lower than those in the control group (1.93 ± 0.84 mmol / L, 3.34 ± 1.12 ) mmol / L, the differences were statistically significant (P <0.01). There was no significant difference in the BMI level between the observation group (24.15 ± 5.75) kg / m 2 and the control group (25.43 ± 6.19) kg / m 2 (P> 0.05). Conclusion Metformin hydrochloride tablets combined with acarbose capsule in the treatment of type 2 diabetes have significant curative effect, which can reduce and stabilize the blood glucose of patients.