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目的 :肺内中性粒细胞 (ＰＭＮｓ)聚集及微血管通透性增高是内毒素活性成分脂多糖 (ＬＰＳ)致急性肺损伤 (ＡＬＩ)的重要发病环节。一氧经氮 (ＮＯ)对微血管通透性的病理生理作用迄今尚无定论。本实验旨在观察气管内滴注ＮＯ供体硝普钠 (ＳＮＰ)能否通过促进ＰＭＮ凋亡 ,减轻肺
PURPOSE: The accumulation of intrapulmonary neutrophils (PMNs) and the increase of microvascular permeability are important pathogenesis of acute lung injury (ALI) induced by lipopolysaccharide (LPS), the active ingredient of endotoxin. The pathophysiological role of nitric oxide (NO) on microvascular permeability has not been elucidated so far. This experiment aimed to observe whether intratracheal instillation of nitric oxide (NO) donor sodium nitroprusside (SNP) could promote PMN apoptosis and reduce lung