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为分析SARS冠状病毒(SARS-CoV)IgG抗体在SARS感染康复者体内的持久性与变化,本研究自2004年3月开始,每年采集北京地区SARS感染康复者血清标本,采用商品化的冠状病毒(变异株)IgG抗体间接ELISA检测试剂盒,对其中22名SARS康复者中的SARS-CoVIgG抗体进行连续五年随访检测与分析。结果表明:在愈后第1年,所有血清SARS-IgG抗体皆为阳性。第2、3年处于平台期,滴度仍维持较高的水平。第4年抗体滴度有明显下降趋势。第5年IgG抗体基本转阴。研究发现SARS-CoVIgG抗体可维持3年以上,第4年之后明显下降。本研究为SARS感染诊断与防治、免疫应答及疫苗效力评价等提供了重要依据。
In order to analyze the persistence and the change of SARS-CoV IgG antibody in SARS-infected individuals who have recovered from SARS infection, the study started from March 2004 to collect the serum samples from SARS-infected patients in Beijing area each year. Commercially available coronavirus (Mutant) IgG antibody indirect ELISA test kit, of which 22 SARS recovered SARS-CoVIgG antibody for five consecutive follow-up testing and analysis. The results showed that all the serum SARS-IgG antibodies were positive at the first year of healing. In the second and third years in the platform period, the titers remained at a high level. The fourth year antibody titers decreased significantly. The fifth year of IgG antibody negative. The study found that SARS-CoVIgG antibodies can be maintained for more than 3 years, after 4 years significantly decreased. This study provides an important basis for the diagnosis and prevention of SARS infection, immune response and vaccine efficacy evaluation.