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系列抗CEA单克隆抗体决定簇图谱分析已显示了抗体的特异性与决定簇的协同性。据此,我们构建了一种抗CEA特异决定簇单抗C_(228)蓖麻毒素A链的免疫毒素。体外细胞毒检测发现,表达对应抗原的人
Serial anti-CEA monoclonal antibody determinant profiling has shown the specificity and determinant synergy of the antibodies. Accordingly, we constructed an immunotoxin that is resistant to the C_ (228) ricin A chain of the CEA-specific determinant. In vitro cytotoxicity assays revealed that the corresponding antigen-expressing human