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目的分析原发性胆汁性肝硬变患者的临床特征与实验室检测特点。方法对 2 0例原发性胆汁性肝硬变患者的临床资料进行回顾分析。结果 2 0例原发性胆汁性肝硬变患者中女 1 8例 ,平均年龄 (52 .4± 1 0 .8)岁 ,男 2例 ,年龄为 2 6、2 7岁 ,主要临床表现为乏力、黄疸、皮肤瘙痒 ;丙氨酸转氨酶 (ALT)、天冬氨酸转氨酶 (AST)有轻度或中度升高 ,碱性磷酸酶 (ALP)、γ 谷氨酰转肽酶 (γ GT)均明显升高 ,多数患者胆红素和直接胆红素与血清IgM升高 ,线粒体抗体及线粒体抗体M2 亚型均为强阳性。结论原发性胆汁性肝硬变的诊断需要结合临床、实验室检查及肝组织病理检查进一步确诊
Objective To analyze the clinical features and laboratory characteristics of patients with primary biliary cirrhosis. Methods The clinical data of 20 patients with primary biliary cirrhosis were retrospectively analyzed. Results Among 20 patients with primary biliary cirrhosis, 18 were female, with an average age of (52.4 ± 1.08) years and 2 males (mean age was 26,27 years). The main clinical manifestations were Fatigue, jaundice and pruritus; ALT, AST were slightly or moderately elevated, alkaline phosphatase (ALP), γ-glutamyl transpeptidase (γGT ) Were significantly higher in most patients with elevated bilirubin and direct bilirubin and serum IgM, mitochondrial antibodies and mitochondrial antibodies M2 are strongly positive. Conclusion The diagnosis of primary biliary cirrhosis needs to be further confirmed by clinical, laboratory and liver histopathological examination