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我科自1991年4月起用环丙氟哌酸治疗46例小儿肺炎。除1例年龄29个月,其余均在4～12岁。治疗前有明显咳嗽,肺部湿性罗音及阳性X线发现。46例中发热45例,10例最高体温>40℃。环丙氟哌酸以15～25mg/kg·d,分2～3次口服,疗程7～14天,并予对症及支持治疗。如治疗5天后体温无下降,病情无好转作无效,改用或加用其它抗菌药物。结果35例痊愈,6例好转,5例无效,有效率为89.1%;其中3天内体温恢复正常者占77.5%,仅3例服药后出现恶心、呕吐,其中1例呕吐呈喷射性,并伴头痛表现,但在停药2天后症状逐渐减轻至消失,未发现骨关节肿痛及运动障碍。所有病例血尿常规检查无异常,27例作肌酐,尿素氮测定均在正常范围,34例作肝功能,2例出现SGPT轻度上升。环丙氟哌酸是新一代喹诺酮类抗菌
My department since April 1991 with ciprofloxacin treatment of 46 cases of children with pneumonia. In addition to a 29-month-old, the rest were 4 to 12 years old. Obvious cough before treatment, lung wet rales and positive X-ray findings. 46 cases of fever in 45 cases, 10 cases of the highest body temperature> 40 ℃. Ciprofloxacin 15 ~ 25mg / kg · d, 2 to 3 times orally, the course of 7 to 14 days, and symptomatic and supportive treatment. Such as the treatment of 5 days after the body temperature did not decline, the disease did not improve for invalid, switch to or add other antimicrobial agents. Results 35 cases were cured, 6 cases improved, 5 cases were ineffective, the effective rate was 89.1%; 3 days, the body temperature returned to normal accounted for 77.5%, only 3 cases of medication after nausea and vomiting, including 1 case of vomiting was jet and accompanied Headache performance, but in the withdrawal of 2 days after the symptoms gradually reduced to disappear, found no joint pain and dyskinesia. All cases of hematuria routine examination without abnormalities, 27 cases of creatinine, urea nitrogen were measured in the normal range, 34 cases of liver function, SGPT mild increase in 2 cases. Ciprofloxacin is a new generation of quinolone antibacterials