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目的探讨心力衰竭严重程度与血清脑钠肽(BNP)变化的关系及其检测的临床意义.方法采用化学发光法分别检测本院2011年4-2012年8月收治的63例心力衰竭患者及35例同期健康者的血清 BNP 水平,并以超声诊断仪采用辛普森法测定患者及健康者的左室射血分数(LVEF),对两组进行比较分析.结果随心力衰竭程度加重,血清 BNP 水平逐渐升高并明显高于健康者,BNP 与左室射血分数(LVEF)成负相关.结论心力衰竭患者血清 BNP 水平浓度升高随心力衰竭程度增加而显著升高.“,”Objective to investigate the heart failure severity and serum brain natriuretic peptide ( BNP ) changes in the relationship and its significance. Methods using chemiluminescence detection of 4-2012 respectively 2011 August treated 63 cases of patients with heart failure and compared with 35 healthy persons serum BNP levels, and ultrasonic diagnostic apparatus using the Simpson method for the determination of patients and healthy persons in the left ventricular ejection fraction ( LVEF ), the two groups were compared analysis. Results the heart failure severity, the serum BNP level increased and was significantly higher than that of healthy subjects, BNP and left ventricular ejection fraction ( LVEF ) negative correlation. Conclusion the level of serum BNP concentration is elevated in heart failure patients with heart failure severity increased remarkably.