蛋白结合的药理学意义所谓结合是指分子量数百以上的药物分子,与分子量几万乃至十几万的蛋白或者体内的大分子发生可逆的干预现象。在研究蛋白结合时,常以纯度较高的白蛋白作为试剂。以下是研究药物与血浆白蛋白结合时要考虑的问题:(1)药物与白蛋白的结合,属离子键还是氢键的结合?还是化学以外的结合;(2)白蛋白分子中哪一个部分对药物具有亲和性;(3)1分子 The pharmacological significance of protein binding The so-called binding refers to the molecular weight of more than hundreds of drug molecules, and the molecular weight of tens of thousands or even hundreds of thousands of proteins or in vivo reversible phenomenon occurs macromolecules. In the study of protein binding, often high purity albumin as a reagent. The following are the questions to be considered when studying the binding of drugs to plasma albumin: (1) whether the drug binds to albumin, whether it is an ionic bond or a hydrogen bond, or a combination other than chemistry; (2) which part of the albumin molecule Affinity to the drug; (3) 1 molecule