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目的:总结卡波西肉瘤(Kaposi’s sarcoma,KS)临床诊断治疗经验,了解病人生存预后情况。方法:回顾性分析25例KS患者,对其临床表现、肿瘤特征、治疗方式、疗效和生存情况进行分析总结。结果:25例均为少数民族,维族24例,哈族1例。经典型KS主要累及四肢,较少发生远处转移。艾滋病相关型KS病变广泛,除皮肤病变外,常多系统器官受累。7例经典型KS采用放疗,平均剂量为3771cGy,近期疗效完全缓解率71.4%(5/7);部分缓解率28.6%(2/7),有效率100%,放疗7例均存活。余11例经典型KS采用化疗,生物免疫等治疗,部分缓解率36.4%(4/11),无完全缓解率,6例存活。7例艾滋病相关型KS患者,以高效的抗逆转录治疗(HAART)以及免疫治疗、生物治疗,其中4例死亡。结论:新疆地区KS以少数民族常见,汉族罕见。放射治疗对KS是一种安全有效的方法,剂量以40Gy左右为宜,同时加生物治疗和化疗可能提高疗效。艾滋病相关的KS治疗疗效和预后差。
Objective: To summarize the experience of clinical diagnosis and treatment of Kaposi’s sarcoma (KS) and understand the prognosis of patients. Methods: A retrospective analysis of 25 cases of KS patients, their clinical manifestations, tumor characteristics, treatment, efficacy and survival were analyzed and summarized. Results: 25 cases were all ethnic minorities, Uygur ethnicity was 24 cases and Kazakh ethnicity was 1 case. Classic KS mainly affects the limbs, less distant metastasis. AIDS-related KS lesions extensive, in addition to skin lesions, often involving multiple system organs. Seven cases of classic KS with radiotherapy, the average dose of 3771cGy, the recent complete response rate of 71.4% (5/7); partial response rate of 28.6% (2/7), the effective rate of 100%, radiotherapy in 7 cases were alive. The remaining 11 cases of classic KS were treated with chemotherapy and biological immunotherapy. The partial response rate was 36.4% (4/11). There was no complete response rate and 6 cases survived. Seven patients with AIDS-related KS were treated with high-efficiency anti-retroviral therapy (HAART), immunotherapy and biotherapy, and 4 of them died. Conclusion: KS is common to ethnic minorities in Xinjiang and Han is rare. Radiation therapy for KS is a safe and effective method, the dose is preferably about 40Gy, plus biotherapy and chemotherapy may improve the curative effect. AIDS-related KS treatment efficacy and poor prognosis.