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经皮冠状动脉介入治疗术后再狭窄的高发病率制约了该技术的发展,再内皮化、促进愈合(而不是阻止愈合)的方法似为防止再狭窄的最为天然的途径。内皮祖细胞是近年来发现的一类能增殖并分化成血管内皮细胞的前体细胞,参与成体血管发生和损伤后血管内皮修复,在促进经皮冠状动脉成形术后受损血管内膜的早期内皮化,抑制新生内膜过度增生,防止再狭窄中有望得到良好应用。
The high incidence of postoperative restenosis after percutaneous coronary interventions has hampered the development of this technology and reendothelialization and therapies that promote healing (rather than prevent healing) appear to be the most natural way to prevent restenosis. Endothelial progenitor cells (EPCs) are a type of progenitor cells that have been found to proliferate and differentiate into vascular endothelial cells in recent years. They are involved in angiogenesis and repair of vascular endothelium after injury. They promote the early vascular endothelial damage after percutaneous transluminal coronary angioplasty Endothelialization, inhibition of neointimal hyperplasia, prevent restenosis is expected to be well applied.