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本文研究了色胺吲啋系统的甲基衍生物的辐射防护活性.借功于动物的存活率单氨基氧化酶对药物的氧化脱氨度以及对动物氧耗量的影响来阐明防护性质的机制。所用药物有1-,2-,4-,5-,6-,7-,β-,甲基色胺,γ-3-吲啋丙胺,δ-3-吲啋丁胺,N-甲基色胺,N′N′二甲基色胺,5-,6-氯色胺等十多种。并简略地介绍了制取它们的方法及它们的辐射防护活性。作者在体外利用肝内的粒线体作为单氨基氧化酶研究了药物的辐射防护活性和它们的氧化脱氨度之间的关系,所用药物采用了与色胺剂量50mg/kg等克分子的剂量,并在夏秋季进
In this paper, we studied the radioprotective activity of the methyl derivatives of the tryptamine system, and elucidated the mechanism of the protective properties by the effect of animal monoamine oxidase on the degree of oxidative deamination and the effect on oxygen consumption of animals . The drugs used are 1-, 2-, 4-, 5-, 6-, 7-, β-, methyltryptamine, γ-3-indapylamine, Tryptamine, N’N ’dimethyl tryptamine, 5-, 6- chlorotamine and other more than 10 kinds. And briefly describes the methods of making them and their radioprotective activity. The authors studied the relationship between the radioprotective activity of drugs and their degree of oxidative deamination using in vitro liver mitochondria as monoaminooxygenase using a dose of equimolar dose of 50 mg / kg , And into the summer and autumn