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【目的】探讨病毒性肝炎患者血清转化生长因子 β1(TGF β1)水平对肝纤维化的诊断价值。【方法】用酶联免疫法测定 143例病毒性肝炎患者血清TGF β1水平 ,并与其中 87例患者的肝组织病理作比较。【结果】慢性肝炎及肝炎肝硬化患者血清TGF β1水平均明显高于正常对照者 (P <0 0 5 )。肝组织炎症活动时 ,血清TGF β1水平明显升高 (P <0 0 5 ) ,但两者之间无显著性相关 (P >0 0 5 )。血清TGF β1水平与肝组织纤维化程度呈正相关 (r =0 6 12 ,P <0 0 5 ) ;肝硬化组血清TGF β1水平明显高于非肝硬化组 (P <0 0 5 )。血清TGF β1水平判断慢性肝炎患者S2 期以上肝纤维化及诊断肝硬化的ROC曲线下面积分别为 0 836和 0 82 8,截断值分别为 80 μg/L和 12 0 μg/L。【结论】动态监测血清TGF β1水平有助于了解肝纤维化的进展情况 ;血清TGF β1有助于判断慢性肝炎患者是否存在S2 期以上的肝纤维化和诊断肝硬化 ,但与肝组织活检相比 ,其诊断价值尚有限
【Objective】 To investigate the diagnostic value of serum transforming growth factor β1 (TGF β1) in patients with viral hepatitis for liver fibrosis. 【Methods】 The levels of serum TGF-β1 in serum of 143 patients with viral hepatitis were measured by enzyme-linked immunosorbent assay (ELISA) and compared with the pathological changes of liver in 87 patients. 【Results】 Serum TGFβ1 levels in patients with chronic hepatitis and cirrhosis were significantly higher than those in controls (P <0.05). Serum levels of TGF-β1 were significantly increased (P <0.05) in liver tissue during inflammation, but no significant correlation was found between the two groups (P> 0.05). The level of serum TGFβ1 was positively correlated with the degree of liver fibrosis (r = 0 6 12, P 0 05). The level of serum TGF β 1 in cirrhosis was significantly higher than that in non-cirrhotic patients (P 0 05). The area under the ROC curve of serum TGFβ1 level in patients with chronic hepatitis with stage S2 or higher liver fibrosis and diagnosis of liver cirrhosis was 0 836 and 0 82 8, respectively. The cut-off values were 80 μg / L and 120 μg / L, respectively. 【Conclusion】 Dynamic monitoring serum TGF β1 level helps to understand the progress of hepatic fibrosis. Serum TGF β1 can help determine whether there is S2 stage or more liver fibrosis and cirrhosis in patients with chronic hepatitis, but not with liver biopsy Than its diagnostic value is still limited