选用了10种典型的P,N-双齿配体并合成相应的Au(I)配合物;以8-甲基喹啉-氮氧化物为氧化剂,Au(I)配合物/金属盐为催化剂,在氧化端炔与硫代酰胺反应制备2,4-二取代噻唑的反应中,考察了不同的金属盐对催化剂性能的影响,优化了反应参数;结果表明,5 mol%Mor-Dal Phos Au Cl/10 mol%Zn(NTf2)2催化体系在该反应中显示出了较高的催化活性,且“一步法”高效地合成了10种2,4-二取代噻唑化合物,为噻唑及其衍生物的制备探索出了一条简便直接的合成路线. Ten typical P, N-bidentate ligands were selected and the corresponding Au (I) complexes were synthesized. Using 8-methylquinoline-oxynitride as oxidant and Au (I) complex as metal salt The effects of different metal salts on the catalyst performance were investigated in the reaction of the oxidized terminal alkyne with thioamide to prepare 2,4-disubstituted thiazole. The reaction parameters were optimized. The results showed that 5 mol% Mor-Dal Phos Au Cl / 10 mol% Zn (NTf2) 2catalytic system showed high catalytic activity in this reaction, and 10 kinds of 2,4-disubstituted thiazole compounds were synthesized efficiently by one-step method. The preparation of its derivatives explored an easy and straightforward synthesis route.