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Objective:To observe therapeutic effect of acupuncture for regulating the liver on depressive neurosis.Methods: In a multi-center randomized controlled trial, 440 patients were divided into 3 groups:Acupuncture group for regulating the liver (Acup., 176 cases) was treated by acupuncture at Siguan Points,I.e. Bilateral Hegu (L14) and Taichong (LR3), Baihui (GV20) and Yintang (EX-HN3) plus ear-acupuncture,Prozac group (P., 176 cases) by oral administration of Prozac, and Non-acupoint needling group (NAN, 88 cases) by acupuncture at non-acupoints as acupuncture placebo. Self-rating Depression Scale (SDS) was examined before treatment, and one month, two and three months after treatment respectively to evaluate therapeutic effect, and Rating Scale for Side Effects (SERS) was used to evaluate the safety. Results: After one month of treatment, SDS scores in Acup. Group were significantly lower than that in P. Group (P<0.05)and than that in NAN Group (P<0.01), and SDS scores in P. Group were lower than that in NAN Group (P<0.05), showing the SDS scores in Acup. Group 0.05), showing the SERS scores in Acup. Group
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