论文部分内容阅读
虽然砜类药物从1941年开始用来治疗麻风,但直到1953年才报道有耐砜类药的初步印象,1964年第一次获得临床和实验室的证据。12年前还认为耐砜类药相当罕见,如今已日见增多。在使用鼠足垫技术的大多数实验室已报道实验证实的耐砜类药的病例。其他许多中心也报道临床证实的耐药,这说明耐氨苯砜(DDS)已成为世界范围的现象。砜类药耐药性问题极为重要:在医疗服务上,因所有的替代药物均较昂贵,且毒性通常较DDS大;对病人来说,复发会延长病期和可能增加组织损伤;对接触者来说,原
Although sulfone drugs have been used to treat leprosy since 1941, the initial impression of sulfone-resistant drugs was not reported until 1953, and clinical and laboratory evidence was first obtained in 1964. 12 years ago also considered sulfite drugs is very rare, is now increasing. Most of the laboratories that use mouse footpad technology have reported cases of sulfone-resistant drugs that have been experimentally confirmed. Many other centers also report clinically confirmed resistance, indicating that dapsone (DDS) has become a worldwide phenomenon. The issue of drug resistance in sulfone is of paramount importance: in the case of medical services, all surrogate drugs are more expensive and generally more toxic than DDS; for patients, relapse prolongs the disease and may increase tissue damage; For the original,