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目的:探讨甘草锌治疗胃溃疡的作用机理。方法:采用应激性、幽门结扎型、醋酸型胃溃疡大鼠模型,观察甘草锌抗溃疡作用以及对病灶组织形态学的影响。结果:甘草锌治疗组溃疡体积小于模型组(P<0.01);溃疡病灶组织学检查与模型组比较,溃疡部位坏死及炎症渗出物减少,肉芽组织内的白细胞,尤其是中性粒细胞减少,疤痕层较厚,显微镜下可见成纤维细胞数量增多、功能增强。结论:甘草锌具有促进肉芽组织增长,促进胃上皮细胞的分裂繁殖,有利于溃疡的修复,从而加快损伤的愈合。
Objective: To explore the mechanism of licorice zinc in the treatment of gastric ulcer. METHODS: The rat model of gastric ulcer of stress, pylorus ligation and acetic acid was used to observe the anti-ulcer effect of licorice zinc and its influence on the histomorphology of the lesion. RESULTS: The ulcer volume of the licorice zinc treatment group was smaller than that of the model group (P<0.01). Compared with the model group, the necrosis of the ulcer site and the inflammatory exudates were reduced in the licorice zinc treatment group, and the white blood cells in the granulation tissue, especially the neutrophils were decreased. The scar layer is thicker, and the number of fibroblasts increases and the function is enhanced under the microscope. Conclusion: Zinc licorice promotes the growth of granulation tissue, promotes the proliferation of gastric epithelial cells, facilitates the repair of ulcers, and accelerates the healing of the lesions.