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目的:研究肺炎支原体(MP)、肺炎衣原体(CP)感染对慢性咳嗽患儿免疫功能的影响,研究其引起慢性咳嗽的可能机制。方法:检测确诊为慢性咳嗽患儿正规治疗前后IL-2、TNF-α、和T淋巴细胞亚群变化,用t检验方法与健康对照儿童进行组间比较。结果:慢性咳嗽患者治疗前CD8+较对照组降低,两组差异显著(P<0.05);CD4/CD8较对照组结果有所增高,组间比较差异有意义(P<0.01)。治疗后CD4/CD8明显降低,组间比较差异有意义(P<0.01)。慢性咳嗽患儿治疗前IL-2、TNF-α水平均显著高于正常对照组(P<0.01)和治疗后(P<0.01),而治疗后IL-2与正常组无统计学差异(P>0.05),TNF-α在治疗后较对照组仍增高(P<0.05)。结论:MP、CP可以诱导慢性咳嗽患者体内T淋巴细胞亚群比例失调,并且引起TNF-α、IL-2等炎性因子分泌增加。
Objective: To study the effect of Mycoplasma pneumoniae (MP) and Chlamydia pneumoniae (CP) infection on immune function in children with chronic cough and to explore the possible mechanism of chronic cough. Methods: The changes of IL-2, TNF-α and T lymphocyte subsets in children with chronic cough diagnosed before and after formal treatment were detected. The t test was used to compare the children with healthy controls. Results: The CD8 + of patients with chronic cough before treatment was significantly lower than that of the control group (P <0.05). The CD4 / CD8 ratio of the control group was significantly higher than that of the control group (P <0.01). CD4 / CD8 decreased significantly after treatment, the difference between the groups was significant (P <0.01). The levels of IL-2 and TNF-α in children with chronic cough before treatment were significantly higher than those in normal control group (P <0.01) and after treatment (P <0.01), while there was no significant difference between the two groups > 0.05). TNF-α was still higher than that of the control group after treatment (P <0.05). CONCLUSION: MP and CP can induce the imbalance of T lymphocyte subsets in patients with chronic cough, and increase the secretion of inflammatory factors such as TNF-α and IL-2.