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目的:探讨肌动蛋白结合蛋白Girdin与非小细胞肺癌(Non small cell lung cancer,NSCLC)侵袭转移的关系及其对预后的影响。方法:应用免疫组织化学法检测167例非小细胞肺癌患者的病理组织标本中Girdin蛋白和MMP-9的表达。结果:在167例组织标本中Girdin蛋白高表达率为38.9%,其表达水平与患者分期、淋巴结转移、远处转移及生存状况密切相关,差异有统计学意义(P<0.05),而与患者性别、年龄、吸烟指数、评分、病理类型及分化程度均无关(P均>0.05)。Girdin蛋白的高表达往往伴有MMP-9的高表达,两者显著相关,且差异有统计学意义(P<0.05)。Kaplan-Meier单因素生存分析显示Girdin高表达为非小细胞肺癌患者预后的不良因素(P<0.05)。COX多因素回归分析显示Girdin的表达水平和分期是判断预后的独立指标(P<0.05)。结论:Girdin蛋白在非小细胞肺癌的侵袭和转移中可能发挥着重要的作用,在判断非小细胞肺癌患者预后方面具有一定的价值。
Objective: To investigate the relationship between actin binding protein Girdin and invasion and metastasis of non small cell lung cancer (NSCLC) and its effect on prognosis. Methods: Immunohistochemistry was used to detect the expression of Girdin protein and MMP-9 in 167 cases of non-small cell lung cancer. Results: The high expression rate of Girdin protein was 38.9% in 167 cases. The expression level of Girdin protein was closely related to the stage of patients, lymph node metastasis, distant metastasis and survival status (P <0.05) Sex, age, smoking index, score, pathological type and degree of differentiation had no correlation (P> 0.05). The high expression of Girdin protein is often associated with high expression of MMP-9, the two were significantly correlated, and the difference was statistically significant (P <0.05). Kaplan-Meier univariate survival analysis showed that Girdin overexpression was a poor prognostic factor in patients with non-small cell lung cancer (P <0.05). COX multivariate regression analysis showed that Girdin expression level and stage were independent prognostic indicators (P <0.05). Conclusion: Girdin protein may play an important role in the invasion and metastasis of non-small cell lung cancer and may be of value in judging the prognosis of patients with non-small cell lung cancer.