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氨基糖苷类抗生素治疗尿路感染有效,但有肾毒性.试验证明其肾毒性作用累及近端肾小管细胞的溶酶体.肾损害在临床上不易测出,仅可通过尿酶活性的增强来判定.已发现某些抗生素类如磷霉素对溶酶体膜起作用,既使在艮他霉素存在的情况下,仍显示出稳定溶酶体的作用.本文研究了艮他霉素与磷霉素(fosfomycin)合并应用的体内、外效应.体外试验用Wister albino鼠,按Morin等人的程序制备溶酶体.结果表明艮他霉素可增加酶活性,而磷霉素则降低这种
Aminoglycoside antibiotics in the treatment of urinary tract infection, but nephrotoxicity test proved that its nephrotoxic effect involving the proximal tubular cells of lysosomes. Kidney damage in clinical difficult to measure, only through the urease activity to enhance It has been found that certain antibiotics, such as fosfomycin, act on the lysosomal membrane and exhibit stable lysosomal activity even in the presence of gentamicin.In this paper, In Vitro and in Vivo Effects of Fosfomycin in Combination In Vitro Lysosomes were prepared using the procedure of Morin et al. In Wister albino mice, and the results showed that gentamicin increased enzyme activity whereas fosfomycin decreased Species