论文部分内容阅读
目的探讨地方性氟中毒病区正常妊娠妇女血清碱性磷酸酶(ALP)在不同孕期的变化特点及其与氟摄入水平的相关性。方法回顾性分析2014年3月—2016年9月确诊的来自地方性氟中毒病区211名正常妊娠妇女的资料,根据B超诊断结果将211名调查对象分为早孕组(51人)、中孕组(84人)和晚孕组(76人);所有妊娠妇女均检测尿氟(UF)和ALP,通过单因素方差分析法比较不同孕期妇女的尿氟和ALP均数,用Pearson相关性检验分析UF与ALP的相关性。结果早、中、晚3组孕妇UF均值分别为(1.16±0.19)mg/L、(1.17±0.17)mg/L和(1.16±0.11)mg/L,中孕组略高于早、晚孕组,差异无统计学意义(F=0.034,P>0.05);早孕组和中孕组妇女的ALP分别为(126.49±20.39)u/L和(135.60±28.60)u/L,虽然中孕组稍高于早孕组,但差异并不明显(Tamhane检验,P>0.05),晚孕组妇女ALP为(206.26±43.27)u/L,高于早、中孕组,组间差异有统计学意义(P<0.05);早孕组(r=0.784)与中孕组(r=0.392)的UF和ALP之间均有相关性(P<0.01),晚孕组UF和ALP之间无相关性(r=0.052,P>0.01)。结论 ALP在正常妊娠妇女的整个孕期的变化为早期不明显、中期轻度升高、晚期明显升高,总体趋势呈抛物型分布;正常妊娠妇女的氟摄入水平与ALP的相关性随孕周增加而减弱,说明病区水氟浓度对妊娠早期ALP的变化有一定影响,改水降氟仍是预防病区妊娠妇女早期并发症的有效措施。
Objective To investigate the changes of serum alkaline phosphatase (ALP) in different stages of fluorosis in normal pregnant women and its correlation with fluoride intake. Methods The data of 211 normal pregnant women from endemic fluorosis area diagnosed from March 2014 to September 2016 were retrospectively analyzed. According to the results of B-ultrasound, 211 subjects were divided into early pregnancy group (51) UF and ALP were detected in all pregnant women. The mean of urinary fluoride and ALP in different pregnant women were compared by one-way analysis of variance (ANOVA), and Pearson correlation Test and analyze the correlation between UF and ALP. Results The mean UF of pregnant women in early, middle and late pregnant women was (1.16 ± 0.19) mg / L, (1.17 ± 0.17) mg / L and (1.16 ± 0.11) mg / L respectively Group, the difference was not statistically significant (F = 0.034, P> 0.05). The ALP in early pregnancy group and middle pregnancy group were (126.49 ± 20.39) u / L and (135.60 ± 28.60) u / L, (P <0.05). The ALP in late pregnancy group was (206.26 ± 43.27) u / L, which was higher than that in early pregnancy group and middle pregnancy group, the difference was statistically significant (P <0.05). There was a significant correlation between UF and ALP in the first trimester (r = 0.784) and the second trimester (r = 0.392) (P <0.01) r = 0.052, P> 0.01). CONCLUSIONS: The changes of ALP in normal pregnant women during the first trimester are not obvious in the early stage, slightly increased in the middle stage, and obviously increased in the late stage. The overall trend of the ALP is parabolic distribution. The correlation between the level of fluoride intake and the ALP in normal pregnant women varies with gestational age Increased and weakened, indicating that the ward water fluoride concentration on the changes of ALP in early pregnancy have a certain impact, water and fluoride is still an effective way to prevent early complications of pregnant women in ward.