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目的：探讨抗凋亡基因ｂｃｌ－２与鼻咽癌发生及与ＥＢ病毒感染的关系。方法：应用ＰＣＲ技术和免疫组化ＳＰ法检测４６例鼻咽癌组织中ＥＢ病毒ＤＮＡ和抗凋亡基因ｂｃｌ－２的表达。结果：３７例ＥＢ病毒ＤＮＡ阳性病例中３１例出现ｂｃｌ－２表达（８３．８％），９例ＥＢ病毒ＤＮＡ阴性病例中有７例呈ｂｃｌ－２阳性反应（７７．８％），两组间无明显差异（Ｐ＞０．０５）。结论：ｂｃｌ－２基因在鼻咽癌中的异常高表达与ＥＢ病毒的感染无明显关系。
Objective: To investigate the relationship between anti-apoptotic gene bcl-2 and nasopharyngeal carcinoma and Epstein-Barr virus infection. Methods: The EB virus DNA and anti-apoptotic gene bcl-2 expression in 46 cases of nasopharyngeal carcinoma were detected by PCR and immunohistochemistry. Results: The expression of bcl-2 was found in 31 out of 37 EBV DNA positive cases (83.8%), and 7 out of 9 EBV DNA negative cases were positive for bcl-2 (77.8%). Two groups There was no significant difference (P> 0.05). Conclusion: The abnormally high expression of bcl-2 gene in nasopharyngeal carcinoma has no significant relationship with Epstein-Barr virus infection.