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作者用双盲试验研究洛哌丁胺治疗急性水泻的有效性和安全性。方法孟加拉国际腹泻研究中心旅行诊所的50例急性水泻患者,24小时稀便均3次以上持续72小时,未曾接受抗生素及辅助治疗。无粘液血便或体温≥39.0℃。新鲜粪标本进行镜检和微生物培养。50例随机分为洛哌丁胺组27例,安慰剂组23例。首剂分别给予2粒胶囊(每粒含洛哌丁胺2mg),以后则排便1次服1粒,每天最多不超过8粒,同时提供口服补液盐,研究进行5天,每天记录
The authors used a double-blind trial of the efficacy and safety of loperamide in the treatment of acute watery diarrhea. Methods Fifty patients with acute watery diarrhea in the Travel Clinic of the International Diarrhea Research Center in Bangladesh were exposed to antibiotics and adjuvant therapy for more than three times in 24 hours. No mucus bloody stool or body temperature ≥ 39.0 ℃. Fresh fecal specimens for microscopic examination and microbial culture. Fifty patients were randomized to loperamide in 27 patients and placebo in 23 patients. The first dose were given 2 capsules (each containing loperamide 2mg), after defecation 1 serving a daily maximum of not more than 8, while providing oral rehydration salts, the study carried out for 5 days, a daily record