消化系产生和分泌激素的细胞,称APUD细胞(参见本刊2(12):540,1975)。这些细胞胚胎时起源于神经嵴,后移向前肠及其衍生物,发育后深埋于一些组织,产生各种多肽激素和胺类,参与消化系和全身功能的调节。目前所知的APUD细胞有24种,胃肠道至少含11种,胰腺有4种(表1)。胃肠道的APUD细胞散布于粘膜细胞之中,其底都紧靠毛细血管的基底膜,在胰腺的则成堆集合而靠 The cells that produce and secrete hormones in the digestive system are called APUD cells (see 2 (12): 540, 1975). These embryos originated from the neural crest and later moved to the foregut and its derivatives. After development, they were deeply buried in some tissues and produced various polypeptide hormones and amines to participate in the regulation of the digestive system and systemic function. Currently, there are 24 APUD cells, at least 11 gastrointestinal tract and 4 pancreas (Table 1). Gastrointestinal APUD cells are scattered in mucosal cells, the bottom close to the basement membrane of the capillaries, while the pancreas is piled together and rely on