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羧肽酶N(又名激肽酶Ⅰ,CN)可灭活缓激肽以及过敏毒素C_3a 和C_5a.现已知CN 有两种同功酶,即CN_1和CN_2.研究表明成人哮喘组与正常组比较CN_1及CN_2均无显著差别;但若将病人按外源性及内源性哮喘分组,则可见显著性差异.为了解儿童哮喘者的CN_1和CN_2与哮喘类型的关系,作者测定了59例儿童哮喘者的CN_1和CN_2.年龄范围4～14岁,于测定CN_1和CN_2前根据简单的临床表现及实验室检查结果(如血清IgE 和外周血嗜酸细胞计数)分为内源性(20例),外源性(20例)及混合性(19例)3个哮喘组。另以30例无哮喘史及无其它过敏性疾病史的儿童作为对照.CN_1和CN_2用分光光密度法测定.
Carboxypeptidase N (also known as kallikrein I, CN) inactivates bradykinin as well as anaphylatoxins C_3a and C_5a. CN is known to have two isozymes, CN_1 and CN_2. Studies have shown that adult asthma group with normal There was no significant difference between the groups CN1 and CN2, but significant differences were found if the patients were grouped according to exogenous and endogenous asthma.To understand the relationship between CN1 and CN2 and asthma in children with asthma, the authors determined 59 Cases of children with asthma CN_1 and CN_2. Age range 4 to 14 years old, before the determination of CN_1 and CN_2 according to simple clinical manifestations and laboratory tests (such as serum IgE and peripheral blood eosinophil count) is divided into endogenous 20 cases), exogenous (20 cases) and mixed (19 cases) three asthma groups. Another 30 children without a history of asthma and no other allergic diseases were used as controls, CN 1 and CN 2 were measured by spectrophotometry.