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目的评价和比较血清IGF-1及CEA、CYFRA21-1联合检测、氟-18-氟代脱氧葡萄糖(18F-FDG)PET/CT及IGF-1联合18F-FDG PET/CT三种方法早期诊断肺癌的临床价值.方法对确诊的18例肺癌患者和1例肺良性病变患者行PET-CT扫描并行血清学IGF-1、CEA和CYFRA21-检测,比较IGF-1+CEA+CYFRA21-1、PET/CT、IGF-1+PET/CT三种方法对肺癌的检出率.结果 IGF-1+CEA+CYFRA21-1组合对肺癌诊断的灵敏度、准确率和假阴性率分别为83.3%(15/18)、78.9%(15/19)和16.7%(3/18);18F-FDG PET/CT显像分别为88.9%(16/18)、89.5%(17/19)和11.1%(2/18);IGF-1+18F-FDG PET/CT组合分别为88.9%(16/18)、89.5%(17/19)和11.1%(2/18).结论 IGF-1+CEA+CYFRA21-1可作为一种很好的筛查肺癌方法;PET/CT显像对肺癌的诊断有较高的价值;IGF-1与PET/CT联合不能提高诊断肺癌的效能.“,”Objective To evaluate the diagnostic value of IGF-1 combined with serum tumor markers CEA and CYFRA21-1,positron emission tomography/computed tomography with fluorine-18-labeled fluoredeoxyglucose(18F-FDG PET/CT),and IGF-1 combined with 18F-FDG PET/CT on lung cancer.Method 18F-FDG PET/CT scan was performed in 18 lung cancer patients diagnosed and 1 patients with benign pulmonary disease.The serum levels of IGF-1,CEA and CYFRA21-1 were detected in the same persons.The sensitivity,accuracy and false positive rate of the combination of IGF-1,CEA with CYFRA21-1,PET/CT and the combination of IGF-1 with PET/CT were analyzed.Results The sensitivity,accuracy and false positive rate of the combination of IGF-1 with serum tumor markers CEA and CYFRA21-1 was 83.3%(15/18),78.9%(15/19) and 16.7%(3/18),respectively;and those of PET-CT scan was 88.9%(16/18),89.5%(17/19) and 11.1%(2/18),respectively;those of the combination of IGF-1 with PET/CT scan was 88.9%(16/18),89.5%(17/19) and 11.1%(2/18),respectively.Conclusion The combination of IGF-1 with serum tumor markers CEA and CYFRA21-1 was an effective screening method on lung cancer.PET/CT was of great value for the diagnosis of lung cancer;Combination of IGF-1 with PET/CT scan cannot enhance significantly diagnostic efficiency on lung cancer.