川芎嗪对小鼠脾淋巴细胞增殖反应的影响与剂量有关。在１００～１０００μｇ／ｍｌ时，川芎嗪对正常小鼠和荷瘤小鼠脾淋巴细胞增殖反应有明显的抑制作用。在亚适浓度ＣＯｎＡ（２μｇ／ｍｌ）作用下，正常小鼠和荷瘤小鼠脾淋巴细胞对川芎嗪的反应性不同，荷瘤小鼠湛服川芎嗪后，其淋巴细胞￣３Ｈ－ＴｄＲ掺人量明显增加，对ＰＨＡ刺激的反应性不因荷瘤而降低，提示川芎嗪具有免疫调整作用。 The effect of tetramethylpyrazine on splenic lymphocyte proliferation in mice is related to dose. In the range of 100-1000 μg/ml, tetramethylpyrazine has a significant inhibitory effect on the proliferation of spleen lymphocytes in normal and tumor-bearing mice. At the suboptimal concentration of COnA (2μg/ml), splenocytes of normal mice and tumor-bearing mice reacted differently to tetramethylpyrazine. After the tumor-bearing mice were treated with ligustrazine, their lymphocytes were mixed with 3H-TdR. The amount of people increased significantly, and the response to PHA stimulation was not reduced by tumors, suggesting that ligustrazine has immunomodulatory effects.