多聚人血清白蛋白(poly-HSA)受体位于乙型肝炎病毒(HBV)DNA 前 S_2[pre-S(2)]基因编码的肽上,肝细胞上亦有相同受体,该受体对 HBV 吸附肝细胞起桥联作用。有实验证明 pre-S(2)基因抗原性比 S 基因强,有 poly-HSA 受体的疫苗免疫原性较无者强。晚近证明 pre-S(2)抗体能中和HBV。作者测定急慢性 HBV 感染血清 pre-S(2)Ag 滴度,阐明其临床意义,探讨 pre-S(2)Ag 和 The poly-HSA receptor is located on the peptide encoded by the pre-S 2 [pre-S (2)] gene of Hepatitis B virus (HBV). The same receptor also exists on hepatocytes On HBV adsorption of liver cells from the role of bridging. Experiments show that the pre-S (2) gene is more antigenic than the S gene, and poly-HSA receptor vaccines are more immunogenic than those without. Recently, it has been demonstrated that pre-S (2) antibodies neutralize HBV. To determine the serum pre-S (2) Ag titer in patients with acute and chronic HBV infection and to elucidate the clinical significance of pre-S (2) Ag and