肌萎缩性侧索硬化(ALS)患者运动神经元内存在IgG,支持异常抗体与ALS病因有关的假说。但是,ALS病人的运动神经元内同时出现了非特异性 血浆蛋白,使问题难以澄清。 本文试图证实:ALS患者运动神经元的IgG是属于免疫特异性,还是非免疫特异性?9例ALS患者,经尸检所得的组织,经10％的福尔马林或4％多聚甲醛固定,脱水后石蜡包埋;切片厚8μm。经脱蜡 The presence of IgG in motoneurons of amyotrophic lateral sclerosis (ALS) patients supports the hypothesis that abnormal antibodies are associated with the etiology of ALS. However, nonspecific plasma proteins appear in motor neurons of patients with ALS, making it difficult to clarify the problem. This article attempts to demonstrate that IgG in motor neurons of patients with ALS is immunospecific or non-immunospecific. In 9 patients with ALS, autopsy tissues were fixed with 10% formalin or 4% paraformaldehyde, Dehydrated and embedded in paraffin; section thickness 8μm. Dewaxing