论文部分内容阅读
目的探讨帕金森病(Parkinson disease,PD)患者的认知功能与血糖水平的关系。方法纳入PD患者200例,进行简易精神量表(mini-mental state examination,MMSE)、蒙特利尔认知量表(Montreal cognitive assessment,Mo CA)、韦氏智力和韦氏记忆的认知评估。将200例PD患者分为PD认知正常组91例,PD认知障碍组109例;另外纳入126例正常对照;比较各组的空腹血糖(fasting plasma glucose,FPG)、餐后2 h血糖(2 h postprandial plasma glucose,2 h PPG)和糖化血红蛋白(glycosylated hemoglobin,HbAlc)水平及糖尿病患病率,并采用二分类logistic回归分析血糖水平对PD患者认知功能的影响。结果 PD患者的FPG、HbAlc水平及糖尿病患病率[5.19(0.72),5.7%(0.5%),14%]都比正常对照组[4.85(0.79),5.6%(0.5%),6%]显著升高(P<0.05)。PD认知障碍患者的FPG水平[5.21(1.32)]较PD认知正常组[4.81(0.95)]相比,显著升高(P<0.05),而2 h PPG、HbAlc都稍有升高,但无统计学差异(P>0.05)。二分类logistic回归分析显示,FPG(OR:1.764;95%CI:0.06~3.244;P=0.068)与PD患者认知功能受损相关无统计学意义。结论高血糖可能是PD的危险因素之一,本研究未发现PD患者认知障碍的发生与血糖水平相关。
Objective To investigate the relationship between cognitive function and blood glucose level in patients with Parkinson disease (PD). Methods 200 patients with PD were enrolled in this study. The cognitive assessment of mini-mental state examination (MMSE), Montreal cognitive assessment (MoCA), Webster’s intelligence and Webster’s memory were performed. 200 cases of PD patients were divided into PD cognitive group 91 cases, PD cognitive disorder group 109 cases, another 126 cases of normal control; fasting plasma glucose (FPG), 2 h postprandial blood glucose ( 2 h postprandial plasma glucose, 2 h PPG) and glycosylated hemoglobin (HbAlc), and the prevalence of diabetes. The dichotomous logistic regression was used to analyze the effect of glucose level on cognitive function in patients with PD. Results The prevalence of FPG, HbA1c and diabetes in PD patients were significantly higher than those in normal controls [5.19 (0.72), 5.7% (0.5%), 14%] [4.85 (0.79), 5.6% (0.5%), 6% Significantly increased (P <0.05). The level of FPG in patients with cognitive impairment [5.21 (1.32)] was significantly higher than that in normal cognitive group [4.81 (0.95)] (P <0.05), while the levels of PPG and HbAlc increased slightly at 2 h But no statistical difference (P> 0.05). Binary logistic regression analysis showed that FPG (OR: 1.764; 95% CI: 0.06 ~ 3.244; P = 0.068) had no significant correlation with cognitive impairment in PD patients. Conclusions Hyperglycemia may be one of the risk factors for PD. In this study, we found no association between the incidence of cognitive impairment and blood glucose level in PD patients.