输血后紫癜是一罕见疾病,主要在输注血液和血小板后2～10天的妇女中发生。现有的患者血小板均为 PI~(AI)阴性,血清中均发现有抗-PI~(AI)抗体。本文报道1例输血后紫癜患者,用血浆置换无效,但大剂量人免疫球蛋白静脉输注后仅4小时,即发生疗效。患者为77岁妇女,在左髋修复手术期间接受3U的低血浆血,1周后又补充了2U。输注次日,出现血尿和鼻衄,患者手臂和腹部有多处乌青块和大面积紫癜。患者既往无出血史,也从未受过血。术前血细胞计数正常,血小板242×10~9/L。第2次输血的次日,血红蛋白为9.2g/dl,白细胞7.2×10~9/L,血小板4×10~9/L。红细胞形态及白细胞分类计数均正常。骨髓示巨核细胞增多。血凝试验和自身免疫检查正常,推断为输血后紫癜,并在血清中检出抗-PI~(AI)抗体而证实。无检出 HLA 抗体。以5%白蛋白液进行两次 Purpura after transfusion is a rare disease that occurs predominantly in women 2 to 10 days after infusion of blood and platelets. Existing patients with platelet are PI ~ (AI) negative serum were found in anti-PI ~ (AI) antibody. This article reports a case of post-transfusion purpura patients with plasma replacement is invalid, but high-dose human immunoglobulin intravenous infusion only 4 hours, that is, the effect. The patient, a 77-year-old woman, received 3U of low plasma blood during a left hip repair operation and 2U after 1 week. The next day after transfusion, there was hematuria and epistaxis, and the patient’s arm and abdomen had many black blocks and a large area of ​​purpura. The patient had no prior history of bleeding and had never had blood. Preoperative blood cell count was normal, platelets 242 × 10 ~ 9 / L. The day after the second transfusion, hemoglobin was 9.2g / dl, leukocytes 7.2x10-9 / L, and platelets 4x10-9 / L. Erythrocyte morphology and white blood cell count were normal classification. Bone marrow megakaryocytes show increased. Hemagglutination test and autoimmune examination were normal, it is concluded that after transfusion purpura, and detected in serum anti-PI ~ (AI) antibody confirmed. No detectable HLA antibodies. With 5% albumin twice