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目的 :研究血浆同型半胱氨酸水平和缺血性脑血管病患者颈动脉粥样硬化斑块的相关性。方法 :选择2014年10月~2015年11月在我院进行诊治的缺血性脑血管病患者500例,进行颈动脉彩色多普勒超声检查后,根据超声结果分为无斑块组(106例)、不稳定斑块组(261例)与稳定斑块组(133例),检测血浆同型半胱氨酸水平,并分析其与颈动脉粥样硬化斑块的相关性。结果 :500例患者中发现无斑块106例(21.2%),颈动脉斑块394例(78.8%);稳定斑块组和不稳定斑块组的血浆同型半胱氨酸水平较无斑块组明显升高;不稳定斑块组与稳定斑块组相比,同型半胱氨酸水平均明显升高;易损斑块组血浆同型半胱氨酸浓度和高同型半胱氨酸血症发生率均明显高于非易损斑块组;Logistic回归分析结果显示同型半胱氨酸的水平与颈动脉硬化斑块呈正性相关关系,OR为1.23,95%CI为1.02 1.22,差异有统计学意义。结论 :颈动脉斑块的形成及其稳定性与同型半胱氨酸水平关系紧密,同型半胱氨酸水平升高是颈动脉斑块形成的独立危险因子。
AIM: To investigate the association between plasma homocysteine level and carotid atherosclerotic plaques in patients with ischemic cerebrovascular disease. Methods: 500 patients with ischemic cerebrovascular disease who were diagnosed and treated in our hospital from October 2014 to November 2015 were selected and examined by color Doppler ultrasonography of carotid artery. According to the results of ultrasound, no plaque group (106 ), Unstable plaque group (261 cases) and stable plaque group (133 cases). Plasma homocysteine levels were measured and their correlation with carotid atherosclerosis plaque was analyzed. Results: There were 106 cases (21.2%) without plaque and 394 cases (78.8%) with carotid artery plaque in 500 cases. The levels of plasma homocysteine in stable plaque group and unstable plaque group were significantly higher than those without plaque Group was significantly higher; unstable plaque group compared with the stable plaque group, homocysteine levels were significantly increased; vulnerable plaque group plasma homocysteine concentration and hyperhomocysteinemia The incidence was significantly higher than non-vulnerable plaque group; Logistic regression analysis showed that the level of homocysteine and carotid plaque was positively correlated, OR was 1.23, 95% CI 1.02 1.22, the difference was statistically significant Significance of learning. Conclusion: The formation and stability of carotid plaque is closely related to homocysteine level. Elevated homocysteine level is an independent risk factor for carotid plaque formation.