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目的 了解病原菌在新生儿败血症中的菌群分布及耐药性 ,指导临床合理用药。方法 对 5 2 3株从新生儿败血症血培养中分离的阳性菌进行回顾性分析。结果 分离的 5 2 3株病原菌中占首位的是葡萄球菌(81.9%) ,其中凝固酶阴性葡萄球菌 (CNS)占 5 3.7%;其次是革兰阴性杆菌 (7.5 %) ,13株大肠埃希菌和 9株肺炎克雷伯菌中ESBLs 13.6 %(3/ 2 2 )。药物敏感试验显示病原菌对氨基糖苷类药物中的阿米卡星及第三代头孢菌素中的头孢哌酮、头孢噻肟有较高的敏感率。结论 新生儿败血症病情发展快 ,临床症状无特异性 ,须引起高度重视 ,并积极抽送血培养以快速确诊及指导合理用药 ;在未获得明确病原菌之前 ,可早期选用阿米卡星、头孢哌酮和头孢噻肟 ,以提高疗效。
Objective To understand the pathogenic bacteria in neonatal sepsis in the distribution of bacteria and drug resistance, and guide clinical rational use of drugs. Methods Retrospective analysis was performed on 523 positive isolates isolated from blood cultures of neonatal sepsis. Results Staphylococcus aureus (81.9%) was the first of the 5 2 3 pathogens isolated, of which coagulase-negative staphylococci (CNS) accounted for 53.7%; followed by Gram-negative bacilli (7.5%), 13 strains of Escherichia coli ESBLs in 13 strains and 9 strains of Klebsiella pneumoniae were 13.6% (3/2 2). Drug sensitivity tests showed that the pathogen had higher sensitivity to cefoperazone and cefotaxime in amikacin and third generation cephalosporins in aminoglycosides. Conclusion Neonatal sepsis develops rapidly and its clinical symptoms are not specific. It needs to attach great importance to it, and it should be actively pumped to blood culture for rapid diagnosis and proper medication. Before the definite pathogens can be obtained, amikacin and cefoperazone And cefotaxime, in order to improve the curative effect.