【目的】探讨影响维持性血液透析患者睡眠质量的相关因素。【方法】将99例维持性血透患者根据匹兹堡睡眠质量指数（PSQI）问卷评分分为睡眠好组（PSQI总分≤5）和睡眠差组（PSQl总分＞5），比较睡眠好组和睡眠差组患者的生化指标及分析影响睡眠质量的原因；logistic回归分析年龄、性别等临床基本资料以及血红蛋白（Hb）、甲状旁腺激素（iPT H ）等生化指标与睡眠质量的相关性。【结果】睡眠好组较睡眠差组Hb、白蛋白（ALB）、Kt/V升高，高敏C反应蛋白（hsCRP）、iPTH、透析前尿素氮、透析前肌酐、碳酸氢钠、钙磷乘积和铁蛋白降低。logistic回归分析示 Hb（OR＝1．051，P ＝0．003）、ALB（OR＝1．209，P ＝0．014）、iPTH （OR＝0．998，P ＝0．043）、钙磷乘积（OR＝0．94，P ＝0．003）与患者睡眠障碍相关。【结论】血液透析患者普遍存在睡眠质量下降，Hb、ALB、iPT H、钙磷乘积可能与患者睡眠障碍有关，须加强对此的识别和控制，以改善患者睡眠，提高患者生存质量。“,”To investigate the sleep quality in patients with maintenance hemodialysis and to ex-plore the influential factors of sleep quality .[Methods]According to Pittsburg sleep quality index (PSQI) score ,99 maintenance hemodialysis patients were divided into good sleep group (PSQI≦5) and poor sleep group(PSQI<5) .The biochemical indicators between good sleep group and poor sleep group were compared . The factors affecting sleep quality was analyzed .Logistic regression method was use to analyze the relationship of clinical general data such as age and sex and biochemical indexes such as hemoglobin (Hb) and immunoreac-tive parathyroid hormone(iPTH) with sleep quality .[Results]Compared with poor sleep group ,Hb ,albumin (ALB) and Kt/V in good sleep group were increased ,while hsCRP ,iPTH ,urea ,creatinine ,sodium bicar-bonate ,calcium-phosphorus product and ferritin before dialysis were decreased .Logistic regression analysis showed that Hb(OR=1 .051 ,P =0 .003) ,ALB(OR=1 .209 ,P =0 .014) ,iPTH(OR=0 .998 ,P =0 .043) and calcium-phosphorus product(OR=0 .94 ,P=0 .003) were associated with sleep quality of patients .[Con-clusion]Sleep quality of hemodialysis patients is commonly decreased .Hb ,ALB ,iPTH and calcium-phos-phorus product may be associated with sleep quality of patients .Recognition and control of sleep quality should be strengthened so as to improve the sleep and increase quality of life of patients .